 | | | |   Phenylalanine 4-monooxygenase |
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TE.59970 | |  Phenylalanine 4-monooxygenase
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définition  | - An enzyme of the oxidoreductase class that catalyzes the formation of L-TYROSINE, dihydrobiopterin, and water from L-PHENYLALANINE, tetrahydrobiopterin, and oxygen. Deficiency of this enzyme may cause PHENYLKETONURIAS and PHENYLKETONURIA, MATERNAL. EC 1.14.16.1.(MeSH)
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termes  | - Phenylalanine 4-monooxygenase
- Phenylalaninase
- Phenylalanine 4-hydroxylase
- EC 1.14.16.1
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termes | - Phenylalanine 4-monooxygenase
- Phenylalanine 4-hydroxylase
- EC 1.14.16.1
- Phenylalanine hydroxylase
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notes | - The active center contains mononuclear iron(II). The reaction involves an arene oxide that rearranges to give the phenolic hydroxy group. This results in the hydrogen at C-4 migrating to C-3 and in part being retained. This process is known as the NIH-shift. The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96, 4a-hydroxytetrahydrobiopterin dehydratase. The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, 6,7-dihydropteridine reductase, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
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